Icand
Itraconazole USP

Composition
Icand 100 mg capsule: Each capsule contains Itraconazole pellets equivalent to Itraconazole USP 100 mg.
Icand 200 mg Tablet: Each film coated tablet contains Itraconazole USP 200 mg.
Icand 100 ml Oral Solution: Each ml oral solution contains 10 mg of Itraconazole USP.
Pharmacology
Icand is a preparation of Itraconazole, an orally active triazole antifungal agent, having broad spectrum activity and favourable pharmacokinetic profile. Itraconazole inhibits cytochrome p-450 dependent enzymes resulting in impairment of the biosynthesis of ergoesterol, a major component of the cell membrane of yeast and fungal cells.
Indication
Icand 100 mg capsule: Tinea corporis, Tinea cruris, Tinea pedis, Tinea manuum, Vulvovaginal candidiasis, Fungal keratitis, Pityriasis versicolor, Oropharyngeal candidiasis, Onychomycosis, Histoplasmosis, Systemic Infections: (Aspergillosis, Candidiasis and Cryptococcus infection when other drugs are ineffective) Antifungal prophylaxis: To prevent systemic
fungal infection in severely neutropenic patients. Icand 200 mg tablet: It is an azole antifungal, indicated for the treatment of onychomycosis of the toenail caused by Trichophyton
rubrum or T mentagrophytes.

Dose & Administration
For oral use only
Tinea corporis, Tinea cruris : 100 mg daily for 2 weeks.
Tinea pedis, Tinea manuum : 100 mg daily for 4 weeks.
Vulvovaginal candidiasis : 200 mg twice daily for 1 day
Fungal keratitis : 200 mg daily for 3 weeks.
Pityriasis versicolor : 200 mg daily for 1 week.
Oropharyngeal candidiasis : 100 mg daily (200 mg for immunocompromised patient patients) for 15 days.
Onychomycosis : 200 mg daily for 3 months; or 200 mg twice daily for 7 days (course), subsequent courses to be repeated after 21 days’ interval; fingernails 2 courses and toenails 3 courses.
Histoplasmosis : 200 mg 1-2 times daily. Systemic Infections: (Aspergillosis, Candidiasis and Cryptococcus infection when other drugs are ineffective) 200 mg once
daily, increased in invasive or in cryptococcal meningitis to 200 mg twice daily. Antifungal prophylaxis: To prevent systemic fungal infection in severely neutropenic patients 100 mg daily.
Oral Solution: The solution should be vigorously swished in the mouth (10 ml at a time) for several seconds and swallowed. Do not rinse your mouth after swallowing the oral solution. Oropharyngeal candidiasis: 200 mg (20 ml) daily for 1 to 2 weeks. Esophageal candidiasis: 100 mg (20 ml) daily for 3 weeks. Child dose: For 1 month to 11 years recommended dose is 3 to 5 mg/kg/day 7 to 30 days.Or as directed by the physician.
Contraindication
The drug is contraindicated in patients with known history of hypersensitivity to it. The drug is also contraindicated in pregnant women and patients with known severe hepatic disease. It is also contraindicated with Rifampicin therapy.
Warnings and Precautions
Hepatic enzyme value should be monitored in patients with pre-existing hepatic function abnormalities. It should also be monitored periodically in all patients receiving continuous treatment for more than one month or at any time a patient develops sign and symptoms suggestive liver dysfunction.
Side Effects
Nausea, abdominal pain, dyspepsia, constipation, headache, dizziness, raised liver enzymes, hepatitis, cholestatic jaundice, peripheral neuropathy has been reported.
Use in Pregnancy and Lactation Not recommended during pregnancy & lactation, unless otherwise indicated by physician.
Use in Children & Adolescents

The efficacy and safety of Itraconazole capsule have not been established in paediatric patients and adolescents.
Drug Interaction
Itraconazole inhibits the metabolism of Cyclosporine and Warfarin. Interaction with Terfinadine, Phenobarbitone, Midazolam has been reported.
Overdose
There is no experience of overdosage with Itraconazole.
Storage
Store below 30°C, protected from light & in a dry place. Keep all medicines out of the reach of children.
Commercial Pack
Icand 100 mg capsule : Each box contains 3X10 capsules in Alu-Alu blister pack.
Icand 200 mg Tablet : Each box contains 3X10 Tablet in Alu-Alu blister pack.
Icand 100 ml Oral Solution : Each amber PET bottle contains 100 ml of Itraconazole oral Solution.