Napgin Plus
Naproxen BP & Esomeprazole USP

Composition
Napgin Plus 375 tablet: Each film coated delayed release tablet contains Naproxen BP 375 mg and Esomeprazole Magnesium Trihydrate USP equivalent to Esomeprazole 20 mg.
Napgin Plus 500 tablet: Each film coated delayed release tablet contains Naproxen BP 500 mg and Esomeprazole Magnesium Trihydrate USP equivalent to Esomeprazole 20 mg.
Pharmacology
Naproxen is a NSAID (Non-steroidal Anti-inflammatory Drugs)with analgesic and antipyretic properties. The mechanism of action of Naproxen is like that of other NSAIDs, related to prostaglandin synthetase inhibition. Esomeprazole is a proton pump inhibitor that suppresses gastric acid secretion by specific inhibition of the H+/K+ ATPase in the gastric parietal cell. By acting specifically on the proton pump, Esomeprazole blocks the final step in acid production, thus reducing gastric acidity.
Indications
Napgin Plus tablet is indicated for the relief of sign and symptoms of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis and to decrease the risk of developing gastric ulcers in patients at risk of developing NSAIDs-associated gastric ulcers.
Dosage and administration
Carefully consider the potential benefits and risks of Napgin Plus and other treatment options before deciding to use Napgin Plus. Use the lowest effective dose of Esomeprazole lower than a total daily dose of 40 mg is more appropriate, a different treatment should be considered.