Generic : Phenoximethyl Penicillin
Thearapeutic : Antibiotics
Pack Size : 100s
Strength :
Dosage Form : Tablet

Biopen VK



  • Biopen VK 250 mg Tablet: Each tablet contains Phenoxymethylpenicillin (Penicillin V) Potassium BP equivalent to 250 mg Phenoxymethylpenicillin (Penicillin V) BP.
  • Biopen VK 100 ml PFS: Each 5 ml reconstituted suspension contains Phenoxymethylpenicillin (Penicillin V) Potassium BP equivalent to 125 mg Phenoxymethylpenicillin (Penicillin V) BP


Biopen VK (Phenoxymethylpenicillin) is acid-stable and is an orally active member of the penicillin family. Biopen VK offers a very convenient means of treating Gram-positive infections but is not indicated for Gram-negative infections involving the respiratory and urinary tracts. Biopen VK has a distinct advantage over penicillin G in resistance to inactivation by gastric acid.

Mode of action

  • It acts by inhibiting the cell wall synthesis of susceptible bacteria.


Oral absorption of the drug is 40% with no presystemic metabolism. Peak serum concentration occurs within 45 minutes and the plasma half-life is about 30 minutes. Plasma protein binding of the drug is 80% and volume of distribution is 0.2L/kg.


                -              Mild to moderate URTI

                -              Tonsillitis

                -              Prophylaxis of rheumatic fever and

                                pneumococcal infection

                -              Otitis media

                -              Erysipelas


Dosage and Administration

  • Adult : 500 mg every 6 hours increased to 750 mg every 6 hours in severe infections,  Child : up to 1 year 62.5 mg 1- 5 years 125 mg,6-12 years 250 mg every 6 hours.
  • The dose should be given 1 h before meals.
  • Use in pregnancy and lactation
  • The drug is safe in pregnancy. Penicillin excreted into human breast milk may lead to allergic reaction in the infant.


  • Biopen VK   is contraindicated in patients known to hypersensitive to penicillin.


  • Common encountered untoward effects include nausea, vomiting, epigastric distress & diarrhoea. The hypersensitivity reactions reported are skin eruptions, urticaria and other serum sickness reactions, laryngeal oedema and anaphylaxis.


  • A modest dose reduction may be appropriate in patients with severe renal failure.

Drug interaction

  • Neomycin reduces absorption and probenecid reduces excretion of penicillin V.

Storage condition

  • Store in a dry place below 30°C. Keep away from light.

Commercial pack

  • Biopen VK 250 mg Tablet: Each box contains 10 x 10 tablets in alu-alu blister strip.
  • Biopen VK 100 ml PFS: Each amber color glass bottle contains powder for the preparation of 100 ml suspension.